Gaming Bolt was able to interview Warren Spector and they asked him about whether or not he wanted to make Epic Mickey a trilogy or even a running series. Here is what Spector said:

Before we started working on the first game at Junction Point, there were reasonably solid ideas floating around for what games 2, 3 and 4 might look like. So, to answer your question, I’d say there are “hopes” that Disney Epic Mickey will enjoy a long run as a series. Will it happen? Let’s see how #2 does!

Before they even started working on the first Epic Mickey, Junction Point was already thinking of potential ideas for a second, third, and fourth game. There is a possibility that the Epic Mickey series will enjoy a long run, but it really depends on how Epic Mickey 2: The Power of Two fares when it releases.